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Wysdom Radio

This masterclass episode breaks down OPuS One , the prospective, multinational study of OsteoCool radiofrequency ablation (RFA) plus cement for painful lytic metastases of the spine and pelvis . Following, there is an expert commentary by Dr. Jason R. Levy of Northside Hospital, Atlanta . The Premise: External beam radiation can take 3 to 6 weeks to relieve bone metastasis pain. OPuS One asked whether ablating the tumor and stabilizing the bone could bring relief faster and keep it. The Study: 206 patients were treated at 15 centers, with lytic or mixed lesions in the thoracolumbar spine, periacetabulum, iliac crest or sacrum. Cement followed RFA in 97% of cases, and technical success was 99%. Efficacy: Worst pain, average pain, pain interference and quality of life improved significantly by day 3, and the improvement was sustained through 12 months. Durability: Complete or partial pain response rose from 53% at day 3 to 74% at 12 months (of n=59), and more patients lowered their opioid dose than raised it at every visit. Safety: Device- or procedure-related adverse events occurred in 6 of 206 patients (2.9%), with no fractures at treated sites. Caveats: OPuS One was a single-arm, industry-funded (Medtronic) study with no comparator and heavy dropout, and the effect of RFA can't be separated from the cement. Expert Take: Dr. Levy explains where ablation and cement fit alongside radiation and systemic therapy in palliative oncology, and what endovascular and image-guided specialists can offer patients with painful bone metastases. Tune in to learn how a single minimally invasive procedure can bring pain relief from bone metastases in days rather than weeks. This podcast is generated using an AI model that has been trained in the context of endovascular surgery and interventional radiology in addition context of the article cited below. The content was reviewed and edited by multiple healthcare professionals in the field. Levy J, David E, Hopkins T, et al. Radiofrequency Ablation Provides Rapid and Durable Pain Relief for the Palliative Treatment of Lytic Bone Metastases Independent of Radiation Therapy: Final Results from the OsteoCool Tumor Ablation Post-Market Study. Cardiovasc Intervent Radiol. 2023;46(5):600-609. https://doi.org/10.1007/s00270-023-03417-x

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Episodes

  1. Ablate (RFA) and Stabilize (Cement): OsteoCool RFA for Painful Bone Metastases, with Dr. Jason Levy (OPuS One)October 21, 2026 · 16 min 20 sec
  2. EMMY at 10 Years: Two-Thirds Avoid HysterectomyOctober 14, 2026 · 19 min 27 sec
  3. Beyond the Drug: What Makes TACE Work?October 7, 2026 · 19 min 48 sec
  4. Infra-popliteal Bioresorbable Stents: The NEJM LIFE-BTK TrialSeptember 30, 2026 · 11 min 53 sec
  5. Fractured IVC Filter Fragments: The Penn PerspectiveSeptember 23, 2026 · 5 min 32 sec
  6. The Golden Era of PE Trials: PRAGUE-26September 16, 2026 · 35 min 58 sec
  7. The Heparin Paradox: When More is LessSeptember 9, 2026 · 15 min 27 sec
  8. Fractured IVC Filter Fragments: When to Chase the MetalSeptember 2, 2026 · 23 min 27 sec
  9. Procedural Path to 91% Complete Pathologic NecrosisAugust 26, 2026 · 21 min 14 sec
  10. Treat the Patient, Not the Picture: Rethinking Pelvic Venous DiseaseAugust 20, 2026 · 18 min 6 sec
  11. The Inguinal Ligament Myth: What Really Drives Stent FailureAugust 12, 2026 · 19 min 34 sec
  12. The TIPS Trade-Off: Bleeding vs. BrainAugust 9, 2026 · 19 min 17 sec
  13. From CTA to the Angio Suite: A GI Bleeding PlaybookAugust 5, 2026 · 22 min 7 sec
  14. 48 Hours to Failure: Anticoagulants and Portal Vein StentsJuly 29, 2026 · 20 min 16 sec
  15. Wrist vs. Risk: Rethinking Transradial Access After MOSAICJuly 22, 2026 · 6 min 24 sec
  16. Venous Stents: How Much Inflow is Enough?July 15, 2026 · 20 min 20 sec
  17. 14 Experts, One Consensus: How to Make Prostate Embolization SaferJuly 8, 2026 · 5 min 54 sec
  18. New PE Guidelines: When to InterveneJune 24, 2026 · 21 min 36 sec
  19. Embolization for Plantar Fasciitis: Technique and Early ResultsJune 17, 2026 · 16 min 43 sec
  20. Why PAE Made the American Urologic Association GuidelinesJune 10, 2026 · 16 min 37 sec
  21. Can Thyroid Embolization Replace Surgery for Nodular Goiter?June 2, 2026 · 5 min 34 sec
  22. Anti-platelets and venous stents: Lessons from ARIVA and C-TRACTMay 26, 2026 · 16 min 21 sec
  23. C-TRACT Trial: Venous Stenting for Post-Thrombotic SyndromeMay 20, 2026 · 18 min 51 sec
  24. Portosystemic Shunt EmbolizationMay 3, 2026 · 21 min 23 sec
  25. The HI-PEITHO Trial: Intermediate Risk PE UnpackedApril 30, 2026 · 17 min 45 sec
  26. SIR 2026 Abstract of the Year: Post-TIPS Liver FailureApril 13, 2026 · 2 min 26 sec
  27. SIR 2026 Abstract of the Year: Endovascular Denervation for Type 2 DMApril 12, 2026 · 2 min 25 sec
  28. The COLLISION Trial ExplainedMarch 31, 2026 · 17 min 53 sec
  29. AHA/ACC 2026 Guidelines for the Evaluation and Management of Acute Pulmonary EmbolismMarch 26, 2026 · 22 min 39 sec
  30. Stanford IR's Dr. Lynne Martin on PAVM TreatmentMarch 9, 2026 · 23 min 24 sec
  31. TIPS for TIPS: The "Best Chance" Protocol by Dr. John Louie (Stanford)March 2, 2026 · 16 min 29 sec
  32. Thyroid Interventions: MWA vs RFA vs EmbolizationFebruary 23, 2026 · 11 min 14 sec
  33. Provocative Mesenteric Angiography from the Author, Dr. Charles Kim from DukeFebruary 17, 2026 · 15 min 9 sec
  34. Night Call Tips from Dr. Rusty HofmannFebruary 9, 2026 · 4 min 44 sec
  35. Y-90 High Lung Shunt: The Mitigation PlaybookFebruary 2, 2026 · 16 min 27 sec
  36. Portal Vein Embolization, Liver Venous Deprivation, and DRAGON Trial DataJanuary 26, 2026 · 13 min 12 sec
  37. Genicular Artery Embolization (GAE) with First-in-Human Resorbable MicrospheresJanuary 20, 2026 · 12 min 45 sec
  38. 5 Keys to Thriving in IR Residency with Dr. Kim Scherer (Cornell IR/DR Associate Program Director)January 6, 2026 · 4 min 5 sec
  39. Y-90 Liver Toxicity: Understanding and Preventing REILDDecember 15, 2025 · 10 min 51 sec
  40. Acute Portal Venous Thrombosis in Non-Cirrhotic Patients: When Anticoagulation Isn't EnoughDecember 12, 2025 · 15 min 4 sec
  41. Provocative Mesenteric Angiography: Safety and Efficacy in Occult GI BleedingDecember 10, 2025 · 13 min 7 sec
  42. Evidence for Intravascular Ultrasound (IVUS) in PADDecember 8, 2025 · 13 min 11 sec
  43. The Must Knows of IR: Part 3 (For first timers in IR)December 7, 2025 · 3 min 59 sec
  44. The Must Knows of IR: Part 1 (For first timers in IR)December 7, 2025 · 5 min 3 sec
  45. The Must Knows of IR: Part 2 (For first timers in IR)December 7, 2025 · 4 min 46 sec
  46. Intro to EmbolicsDecember 5, 2025 · 12 min 27 sec
  47. MSK Embo - Possible ApplicationsDecember 5, 2025 · 14 min 15 sec
  48. IVC FiltersDecember 5, 2025 · 6 min 28 sec
  49. Portal Hypertension, TIPS, and RTO—Latest AASLD GuidanceDecember 3, 2025 · 16 min 44 sec
  50. Bronchial Artery Embolization (BAE)December 3, 2025 · 15 min 19 sec
  51. The Evolution of Cryoneurolysis: Regulatory Shifts and New TargetsDecember 3, 2025 · 15 min 20 sec
  52. STORM-PE Trial Explained (Computer-Assisted Vacuum Thrombectomy by Penumbra)December 3, 2025 · 16 min 29 sec
  53. Bleeding Stomal VaricesNovember 30, 2025 · 14 min
  54. CREST-2 Trial Explained (Carotid Stenosis Treatment)November 22, 2025 · 16 min 30 sec